Quarterion Johnson, 31, also was indicted on four counts of aggravated assault, driving on a revoked license, leaving the scene of an accident involving death or injury, reckless driving, no insurance and failure to yield with serious injury or death.
He is being held on $25,000 bond.
The incident occurred around 5 p.m. on Nov. 4 at Saratoga and Grand in Orange Mound.
Investigators said Johnson was driving a 2000 Ford Taurus at a high rate of speed eastbound on Saratoga at Grand where he ran a stop sign and struck a red Mitsubishi that was northbound on Grand.
The impact spun the Mitsubishi into a group of four people who were standing on the northeast corner of Saratoga and Grand. Two teens and two adults were taken to the hospital, including 55-year-old Willie Smith who died several hours later.
Johnson drove off, but turned himself in to police the next morning.